N-Methyl-N-nitroso-p-toluenesulfonamide (Diazogen) (C8H10N2O3S), 25 grams

N-Methyl-N-nitroso-p-toluenesulfonamide (Diazogen) (C8H10N2O3S), 25 grams

• Volume: 25g
• CAS: 80-11-5
• Formula: C8H10N2O3S
• Molecular Weight: 214.24
• UN Number: 3224
• Product Type: Building Blocks, Organics
• Harmonized Tariff Code: 29351000
• Storage: 2 to 8°C

Chemical Name: N-Methyl-N-nitroso-p-toluenesulfonamide  

CAS Number: 80-11-5

Molecular Formula: C₈H₁₀N₂O₃S

Synonyms: Diazald, N-Methyl-N-nitroso-p-toluenesulfonamide, N-Methyl-N-nitrosotoluene-4-sulphonamide, Diazale, DIAZOGEN

 Applications: N-Methyl-N-nitroso-p-toluenesulfonamide, well-known as Diazald and Diazogen, is a useful and safe reagent for the generation of diazomethane, a reactant used is organic synthesis to methylate organic molecules such as fatty acids, phenols, heterocycles, and a myriad of chemical scaffolds generating new compounds and analytes for chemical analysis. With these properties Diazogen is favored for the synthesis of diazomethane, compared to reagents like N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine, which are toxic, mutagenic and thermally unstable.

Reaction Methods: To prepare diazomethane, in the past, chemists used especially designed apparatuses that were devoid of ground glass joints, which causes diazomethane to explode dangerously, and special precautions and training were needed. Using new methods and reagents such as diazogen or diazald, ordinary glassware is used and potassium hydroxide is used to generate the diazomethane, which is distilled in the reaction with ether and added to the substrates.  

Uses in Analytical Chemistry-Biochemistry of Un-esterified Lipids: Unesterified lipids are readily detected as the methyl esters in cellular extracts.

References

Black, H., The Preparation and Reactions of Diazomethane, 1983, Aldrichchimica Acta 16(1):3

Schmid PC, Schmid HH. Reactions of diazomethane with glycerolipids in the presence of serum or inorganic salts. Lipids. 1994 Dec;29(12):883-7. doi:  10.1007/BF02536257. PMID: 7854015.

Product Specifications
Material Safety Data Sheet

Hazard Statements:
H242: Heating may cause a fire
H302 + H312 + H332: Harmful if swallowed
in contact with skin or if inhaled
H315: Causes skin irritation
H317: May cause an allergic skin reaction
H319: Causes serious eye irritation

Precautionary Statements:
P210: Keep away from heat/sparks/open flames/hot surfaces. No smoking
P235: Keep cool
P260: Do not breathe dust/fume/gas/mist/vapours/spray
P264: Wash thoroughly after handling
P280: Wear protective gloves/protective clothing/eye protection/face protection
P301+330: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
P315: Get immediate medical advice/attention

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Terms & Conditions

These chemicals are for professional manufacturing, research laboratories and industrial / commercial usage only. Not for medical or consumer use. We currently cannot ship this product to doctor offices, pharmacies, medical facilities, veterinarians or residences. All orders are verified prior to shipment. Orders shipping to consumers or medical facilities will be canceled.

Please note: This product is not returnable. Chemicals cannot be expedited.